He specialises in the defence of executives in complex, large-scale proceedings and in the defence against criminal charges in connection with the issue of investment products in the regulated and unregulated capital markets. Furthermore, he has in-depth factual and legal knowledge in the area of the Weapons Act and repeatedly defends clients in corresponding criminal proceedings.

He has been and continues to be involved in a wide range of major criminal proceedings. Examples include the defence of a former board member of a German car manufacturer in connection with allegations of manipulation of exhaust systems in diesel vehicles, the defence of a bank employee against allegations arising from the"cum/ex" complex, the defence of the president of a popular sports association against allegations of tax evasion and the defence of an on cologistin proceedings brought by the Hamburg public prosecutor's office concerning the billing of cytostatics.

The JUVE Handbook of Commercial Law Firms 2021/2022 names Dr. Matthias Dominok as a frequently recommended lawyer for the advice/defence of individuals in commercial criminal law ("reliable, collegial, combative", "also delivers the best and prudent results in interdisciplinary cooperation").

He has been consistently listed by Focus as a "Top Lawyer in Criminal Law" since 2019. Handelsblatt, in cooperation with Best Lawyers, has listed him in the annual ranking for "Commercial Criminal Law" since 2021, and since 2023 also in the area of "Criminal Tax Law".